SSF Grant

Björn Högberg was just awarded with a 10 MSEK grant from the swedish foundation for strategic research (SSF) to continue to develop DNA nanotechnology for biomedical research over the next five years.

WTN nomination

Björn Högberg was nominated for last years World Technology Awards in the Biotechnology (Individuals) category.

European Network

The lab is a proud member of the European School of DNA Nanotechnology (EScoDNA).

Publication in Small!

Origami folding, now directly from phage and in huge chunks. Check it out here.

Publication in Nature Methods!

Check out our publication page, the news at ki.se or the publication itself on NPGs website.

Contact

For any requests about the lab or this site, send your e-mail to Björn Högberg or call Björn on: +46 852 48 70 36. Our webpage on The Karolinska Institutets web can be found here.

 

Research Focus

The emergent field of DNA nanotechnology and DNA origami is at the core of our research. The discoveries over the last few years in this field in this exciting field, has given us unrivaled positional control of matter at the nanoscale.

We aim to use the self-assembly properties of DNA to build new molecular machines, scaffolds for exact positioning of proteins or other molecules and to develop new techniques produce DNA nanostructures using multiplexed selection processes.

Exploring DNA devices for diagnostics and therapeutics

Ultimately, nanoscale DNA devices promise to find applications such as molecular sensors to be used for diagnostic devices or molecular drug containers and actuators for therapeutic use. The aim of this lab is to develop techniques to bring DNA devices to practical use in Medicine. Our location within the Department of Neuroscience at the Karolinska Institutet and The Swedish Medical Nanoscience Center provides an excellent environment for this multidisciplinary effort.

 


Using DNA as a construction material

By using the method of DNA origami , we are able to design and fabricate nanoscale devices as if we were using macro-scale techniques. This video of a cross-like structure shows the stylized design of a nanostructure that was later rendered in DNA, measuring about 40 nm across and comprising 8642 base-pairs.

The diagram shows how one circular, single strand, of DNA is able to form a cross shape by winding back and forth through the structure.

 

Transmission Electron Microscope images of the completed DNA nanostructures from the video above. The scale bars are 20 nm.