Post-doc position

Join our team. We are looking for highly motivated post-doc candidates who aim to be independent researchers and want to aid us in our quest to develop cool new methods using synthetic biology to produce DNA/protein nanostructures.
Follow this link and apply here!

Publication in NAR!

Rolling circle replication, maybe not so rolling? Read our new paper here.

Björn will speak at nov2k

Björn Högberg will be a Keynote speaker at the nov2k conference taking place this fall November 20-21.

New paper in Nature Methods!

The nanocalipers are here! The news at ki.se and the publication itself on NPGs website.

Publication in Small!

Origami folding, now directly from phage and in huge chunks. Check it out here.

Contact

For any requests about the lab or this site, send your e-mail to Björn Högberg or call Björn on: +46 852 48 70 36. Our webpage on The Karolinska Institutets web can be found here.

 

Research Focus

The emergent field of DNA nanotechnology and DNA origami is at the core of our research. The discoveries over the last few years in this field in this exciting field, has given us unrivaled positional control of matter at the nanoscale.

We aim to use the self-assembly properties of DNA to build new molecular machines, scaffolds for exact positioning of proteins or other molecules and to develop new techniques produce DNA nanostructures using multiplexed selection processes.

Exploring DNA devices for diagnostics and therapeutics

Ultimately, nanoscale DNA devices promise to find applications such as molecular sensors to be used for diagnostic devices or molecular drug containers and actuators for therapeutic use. The aim of this lab is to develop techniques to bring DNA devices to practical use in Medicine. Our location within the Department of Neuroscience at the Karolinska Institutet provides an excellent environment for this multidisciplinary effort.

 


Using DNA as a construction material

By using the method of DNA origami , we are able to design and fabricate nanoscale devices as if we were using macro-scale techniques. This video of a cross-like structure shows the stylized design of a nanostructure that was later rendered in DNA, measuring about 40 nm across and comprising 8642 base-pairs.

The diagram shows how one circular, single strand, of DNA is able to form a cross shape by winding back and forth through the structure.

 

Transmission Electron Microscope images of the completed DNA nanostructures from the video above. The scale bars are 20 nm.