Nature Methods Publication!
The research focus is on enabling technologies for therapeutics and diagnostics. Specifically we are exploring the use of the novel platform that is DNA nanotechnology and DNA origami.
The lab is now a proud member of the European School of DNA Nanotechnology (EScoDNA). In this Marie Curie ITN network we will participate in research training of PhD students with funding for 2 students in our lab.
The emergent field of DNA nanotechnology and DNA origami is at the core of our research. The discoveries over the last few years in this field in this exciting field, has given us unrivaled positional control of matter at the nanoscale.
We aim to use the self-assembly properties of DNA to build new molecular machines, scaffolds for exact positioning of proteins or other molecules and to develop new techniques produce DNA nanostructures using multiplexed selection processes.
Exploring DNA devices for diagnostics and therapeutics
Ultimately, nanoscale DNA devices promise to find applications such as molecular sensors to be used for diagnostic devices or molecular drug containers and actuators for therapeutic use. The aim of this lab is to develop techniques to bring DNA devices to practical use in Medicine. Our location within the Department of Neuroscience at the Karolinska Institutet and The Swedish Medical Nanoscience Center provides an excellent environment for this multidisciplinary effort.
Using DNA as a construction material
By using the method of DNA origami , we are able to design and fabricate nanoscale devices as if we were using macro-scale techniques. This video of a cross-like structure shows the stylized design of a nanostructure that was later rendered in DNA, measuring about 40 nm across and comprising 8642 base-pairs.
The diagram shows how one circular, single strand, of DNA is able to form a cross shape by winding back and forth through the structure.